Lesley H. Curtis is Professor and Chair of the Department of Population Health Sciences at the Duke University School of Medicine. A health services researcher by training, she is a national leader in the use of health care data for clinical outcomes and health services research, as well as in efforts to improve data quality and infrastructure for research and policy. She is co-Principal Investigator of the NIH Pragmatic Trials Collaboratory, which aims to expand national capacity for large-scale pragmatic trials embedded in health care delivery. She is also a co-Investigator of the coordinating center for PCORI’s National Clinical Research Network (PCORnet), which partners with health systems and patient networks to enable robust observational and interventional research using harmonized electronic health record data. Lesley previously served as co-Principal Investigator of the FDA Sentinel Innovation Center and as a co-Investigator in the Sentinel Data Core, helping to advance the FDA’s use of real-world data for medical product safety. From 2018 to 2020, she served as Interim Executive Director of the Duke Clinical Research Institute, and from 2023 to 2025, she was Senior Policy Advisor at the U.S. Food and Drug Administration, supporting the Agency’s post-market evidence generation initiative.